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We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli , and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.more » « less
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Singh, Sylvia ; Nimmagadda, Alekhya ; Su, Ma ; Wang, Minghui ; Teng, Peng ; Cai, Jianfeng ( , European Journal of Medicinal Chemistry)
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Niu, Youhong ; Wang, Minghui ; Cao, Yafei ; Nimmagadda, Alekhya ; Hu, Jianxing ; Wu, Yanfen ; Cai, Jianfeng ; Ye, Xin-Shan ( , Journal of Medicinal Chemistry)
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Gide, Mussie ; Nimmagadda, Alekhya ; Su, Ma ; Wang, Minghui ; Teng, Peng ; Li, Chunpu ; Gao, Ruixuan ; Xu, Hai ; Li, Qi ; Cai, Jianfeng ( , Macromolecular Rapid Communications)